Saturday, August 31, 2019
Miranda Assignment
Miranda warnings are based on the U.S. Constitution. The U.S. Supreme Court initially laid down this principle in the case of Miranda v. Arizona (384 U.S. 436) and was affirmed in the case of U.S. v Charles Dickerson (530 U.S. 428) that the Miranda warnings are guarantees to ensure the protection of the rights of the criminal suspect during police investigations. These constitutional rights refer to the right to have counsel, the right against self incrimination and a general basic right to due process (Escobedo v. Illinois, 378 U.S. 478) .The criminal suspect is supposed to be informed and advised of his constitutional rights by reading to him the Miranda warnings during custodial investigation or interrogation (Miranda v. Arizona, 384 U.S. 436). Custodial investigation is defined as ââ¬Å"questioning initiated by law enforcement officers after a person is taken into custody or otherwise deprived of his or her freedom in any significant wayâ⬠(West's Encyclopedia of American L aw, 1998).The rationale for this is the fact that in custodial investigations there is the tendency of law enforcement or police officers to coerce the criminal suspect. There is also the likelihood for the criminal suspect by reason of fear during the antagonistic environment, to lie to defend himself or admit to the commission of the offense or criminal act being investigated. The Miranda warnings are supposed to protect the suspect from being intimidated and making forced confessions by reason of the strategies that may be employed by the law enforcement officers [Illinois v. Perkins, 496 U.S. 292 (1990)].The Court interpreted the meaning of ââ¬Ëcustodyââ¬â¢ as one which restricts the physical movement of the suspect (Orozco v. Texas, 394 U.S. 324). It may also occur even if the inquiry or interview is non-confrontational [Oregon v. Mathiason, 429 U.à S. 492 (1977)}.In the instant case, Police Officer Watson should have advised the suspect of the Miranda warnings before h e asked him questions. The suspect is deemed to be under custodial interrogation already even if at the time Officer Watson asked the question, they are not in the police station yet. The custodial investigation is deemed to have commenced when Officer Watson started to ask the suspect.As the court ruled in the case of Orozco v. Texas, a criminal suspect is deemed to be under custody even if he is in the comfort of his own home when his freedom of movement is restricted (Orozco v. Texas, 394 U.S. 324). It is noteworthy to point out as well that Officer Watson failed to inform the suspect of his rights when he was brought to the police station for interrogation. Consequently, the statements made by the suspect shall be deemed inadmissible against him during trial except to impeach his own testimony in consonance with the exclusionary rule doctrine (Walder v. United States, 347 U.S. 62 (1954).Under the probable cause doctrine, the Miranda warnings are no longer necessary. Law enforcem ent officers are required by law to have probable cause before arresting a suspect. Probable cause is defined as ââ¬Å"a level of reasonable belief, based on facts that can be articulated, that is required to sue a person in civil court or to arrest and prosecute a person in criminal courtâ⬠(West's Encyclopedia of American Law, 1998).The suspectââ¬â¢s answer to the first question of Officer Watson cannot affect the admissibility of confession because there was lack of coercion to force the suspect in making such a statement. The important factor to be determined is whether the suspect made his statement knowingly and voluntarily, a doctrine enunciated by the Court in the case of Oregon v. Elstad [Oregon v. Elstad, 470 U.S. 298 (1985)].ReferencesDickerson v. U.S., 530 U.S. 428. Retrieved on April 15, 2008, from à à à à à à http://caselaw.findlaw.com/us-supreme-court/530/428.htmlEscobedo v. Illinois, 378 U.S. 478. Retrieved on April 15, 2008, fromhttp://cas elaw.findlaw.com/us-supreme-court/378/478.htmlIllinois v. Perkins, 496 U.S. 292 (1990). Retrieved on April 15, 2008, fromhttps://www.oyez.org/cases/1989/88-1972
Friday, August 30, 2019
Gothic Architecture
The fall of the Roman Empire and the events that occurred in Europe leading up to the Middle Ages (has) have had a lasting effect on architecture and design today. The enduring values of medieval art and architecture can be split up into five major styles, early Christian, Byzantine, Islamic, Romanesque and Gothic. The most influential period was the Gothic, which is known for its significant change from classical architecture; this change from classical architecture aided in the Gothic era's transformation to its own identity.The Medieval period is known for its constant airfare and battle, and most people feared death and eternal damnation; the Catholic Church gained its wealth and power through people's fear. Due to the high level of religious devotion during this time, it is evident that church leaders, such as the Pope had more power than Kings and Queens. Even serfs wanted to maintain a relationship with God, so they paid small fees to be part of the church. Scott, page 149) Ca thedrals and churches were sacred spaces, an escape from the hardship and brutality of life, indicating that religion during this time was the most important influence in medieval culture, art, and architecture. It is evident in the monumental cathedrals and churches. Many argue that art and design weren't important during Medieval times. It is evident, however, through careful observation of monumental cathedrals and churches built during the early Middle Ages that the time period cherished art and design, rather than disregarded it.Religion was the most central aspect to life, and the intricate and divine detail included in these places of worship, such as the Notre Dame Cathedral show that art and design was very much appreciated. During the time of the Roman Empire, soldiers protected the middle and lower classes until it fell. The law then no longer protected the individuals, so they turned to the Lords to keep peace and protection. Thus began a period of time called the middle ages and the start of feudalism, which existed for over a century.Everyone's life was lived out against a backdrop of fear; fear of violence, bloodshed, brutality, fear of starvation, fear of dying, and fear of ones fate in the afterlife. Famine and sickness were major factors in death during this time, considering they depended on ropes and agriculture to prosper, and the cold climate led to less food on their plates and nothing to sell at the market. Even when food was abundant, serfs still lacked a dependable source of essential vitamins, leaving them weak and vulnerable to death.Their water was polluted and there were no sanitation systems, which often led to epidemics. They lived in hovels that were poorly wood constructed shelters that had no indoor heating; no windows to bring in natural light and generally caught fire. (Cantor, page 383) Their only defense against living in these harsh environments was elision; faith in God was their only hope for salvation in the after lif e. People also believed when misfortune struck, whether in the form of fire, drought, famine, and war, that they had failed God. Constantine the Great was considered to be the last great emperor of Rome.Although his reign was before the middle ages, he played an important transitional role in history through his recognition of Christianity, which became the prominent religion in Europe until the Reformation. Due to the fact that civilization survived in such harsh living conditions, the Christian faith brought everyone together in a more positive light and shaped their lives from birth to death; their purpose on earth was to serve god, who was above them. Humanism wouldn't make its presence known until the beginning of the renaissance, which was not until a century later, and society was Just adhering to the norm.Following the norm gave them great security, physically and emotionally. In any society that thrived for protection from the harshness of life through religion, people look ed to however could secure your happiness in heaven; this person had the most political and cultural power. The Roman Catholic church was the supreme power during the Middle ages, and the laws of the land and leading roles of government were all in the hands of church leaders such as bishops and archbishops. The Pope was considered the most powerful, as he was God's representative on earth.Although priests and kings had their individual responsibilities from the church, priests had a commitment to God, to communicate with him on behalf of the people, handing down Gods rules of conduct, where as the King was responsible for the people to adhere to those rules of conduct; he was noninsured God's Solider. The king had lords and nobles who served him, controlling the land in exchange for protection of the serfs, villains or peasants. To maintain such an operation, one might have as many as 500 serfs in his household, while those lower on the social scale might have an average of 70.Sinc e the church had extensive land holdings, it had great leverage in structuring feudalism (Blackmore, Robbie, page 68). The definition of feudalism is, ââ¬Å"A political and economic system of Europe, based on the holding of all land in fief or fee and the resulting relation of rod to vassal and characterized by homage, legal and military service of tenants, and forfeiture. â⬠(Cantor, page 164) Feudalism is known for its negative connotation; however, it still gave people a reason for salvation, and aided in their interest in a higher existence.Feudalism put fear in society's eyes, yet funded the construction of the cathedrals, which ironically had the opposite effect. Cathedrals were one response to the unsettling conditions of such a feudal society, but also became powerful and emotional masterpieces bringing the image of heaven to earth. These places of worship would serve to the lower classes and became city landmarks, a place where the village could experience solidarity. Together cathedrals and the cities they resided in would prosper. Having centered themselves in the heart of the town, places of worship brought people from the countryside to the center of the city (Scott, page 69). Unlike the more classical based architecture that came before it, the Romanesque style, Gothic architecture was built with excess. The Gothic characteristics strove for extreme proportions and dimensions; this created new structures to heighten the buildings, as well as improving window sizes to bring in enough light. Gothic architecture had wider windows and doors than those of Romanesque buildings.According to their understanding, ââ¬Å"light is a substance, yet it differs from other substances through its ability to penetrate glass or precious stone without splitting themâ⬠(Hovercrafts, page 51). The flying buttresses, pointed arches, ribbed vaults, soaring ceilings, and stained glass windows characterize gothic design, making it functional, yet dramatically appealing. They clearly understood the importance of light, and how bringing that element into the building changed people's perceptions and attitudes. Notre Dame Cathedral is one of, if not the most profound example of gothic architecture.Construction of Notre Dame began under the direction of Maurice De Sully, Bishop of Paris in 1163. Geometric proportioning was fundamental for gothic design, which also led to the flying buttresses. When Notre Dame started its construction the walls were so thin, that arches on the exterior had to support the vertical and narrow proportions. The flying buttresses were not originally exposed and didn't become acceptable until the end of the 12th Century. Cathedrals during this time were competing to be the tallest, which symbolized wealth and power (Scott, peg 94). Geometric proportion was indeed a constant preoccupation in the middle ages,â⬠(Gridlock, page 14) and this created a whole new style for the nave and an increase in the size of the stain glass windows. This cathedral's high alter was consecrated in 1189, and the nave was finished around 1196. The west faded of Notre Dame was completed between 1225 and 1230. The west faded displays an important characteristic to the gothic style, the rose window, which has many efferent conceptions on its significance.Relating back to the Romans and the culls centered upon the Pantheon in Greece, some view it as the symbol of the sun, and God, also as its original form a flower which represents Mary, and lastly, heavenly Jerusalem, which is known to be a round city (Hovercrafts peg 50). Not only did the window symbolize god, but also the shape of the building as well, The Latin Cross was the architectural shape of the building, as if God was looking down from heaven recognizing their faith. The towers topping the west faded were completed around 1250.It took over 200 ears to complete, taking into consideration the climate, need for materials and transportation, labor, and warf are. A tremendous amount of effort implies the importance the cathedral had to the population. Abbot Surer believed, ââ¬Å"everything that is most precious should be used above all to celebrateâ⬠. Abbot Surer was an influential leader during his time and patron of the arts. He was a classmate and friend to the future King Louis VI, who later appointed him Abbot of church Saint-Denis (Cantor, page 398 ).His duty was to enhance the stature of the church Saint-Denis, and under his power the church was renovated so rustically that it has become the first example of the Gothic style also known as the ââ¬Å"heavenly capitalâ⬠. Light was the primary source of faith and divine inspiration, opening up the dark Romanesque walls and cramming it with aisles and replacing the clerestory windows with stained glass. Stained glass is another important element to the cathedral's design; one of the oldest surviving stained glass windows dates back to 1065, and can be found in the Cathedra l of Sagebrush in Germany. (Cantor, page 397) www. Sobs. Rag Popular designs depicted scenes from the bible as well as the lives of the Saints. Some also illustrated everyday life, showing Artisans at work. Romanesque cathedrals had such thick walls and small windows, they provided poor light, whereas Gothic cathedrals had windows so large that the stained glass would lay out on an entire floor. Understanding that light symbolized God, as the light came through the colored glass, often gave individuals a feeling of intense spirituality, not only illuminating the church, but them as well. Since few people could read or write, the windows also gave them a source of religious instruction.Sculptures were used as well throughout dihedral history. Sculptures of little monsters called Gargoyles conveyed more then one message, primarily to instill fear into the city. These Gargoyles represented the evil on earth, but were also said to scare off evil spirits, assuring citizens that it was a holy place. (Cantor, page 397) Ornamentation throughout the middle ages gave people an understanding to life and glorifying god. Over 80 cathedrals, and 500 abbey churches were built in the gothic style, (Cantor, page 104) astonishing monuments of Gods glory, each remained intact until the reformation.Cathedrals didn't build over night, like today with skyscrapers that take six years to build. It took up too two hundred years, some generations wouldn't even get to see them completed although worked on them their whole life. Workers would use the most basic tools, and the number of tools required for such a task were quite small, for example hammer, epic and axe, saw; working in conditions that modern day health and safety laws would forbid today. (Scott, page 21) It clearly shows the importance of these building to the people during that time period.Everything about he medieval cathedral, special use of light, layout, and sculptors are all inspirations of God. People feared that fai lure to use the best human creativity might be interpreted by the God as something less than full devotion, so they felt compelled to use all of their artistic, engineering and craft based creative individuals to create the finest space they were capable to build. Architecture was their doorway to a better life and as evidence shows the monumental cathedrals and churches built during the early Middle Ages were cherished art and design. Gothic Architecture The fall of the Roman Empire and the events that occurred in Europe leading up to the Middle Ages (has) have had a lasting effect on architecture and design today. The enduring values of medieval art and architecture can be split up into five major styles, early Christian, Byzantine, Islamic, Romanesque and Gothic. The most influential period was the Gothic, which is known for its significant change from classical architecture; this change from classical architecture aided in the Gothic era's transformation to its own identity.The Medieval period is known for its constant airfare and battle, and most people feared death and eternal damnation; the Catholic Church gained its wealth and power through people's fear. Due to the high level of religious devotion during this time, it is evident that church leaders, such as the Pope had more power than Kings and Queens. Even serfs wanted to maintain a relationship with God, so they paid small fees to be part of the church. Scott, page 149) Ca thedrals and churches were sacred spaces, an escape from the hardship and brutality of life, indicating that religion during this time was the most important influence in medieval culture, art, and architecture. It is evident in the monumental cathedrals and churches. Many argue that art and design weren't important during Medieval times. It is evident, however, through careful observation of monumental cathedrals and churches built during the early Middle Ages that the time period cherished art and design, rather than disregarded it.Religion was the most central aspect to life, and the intricate and divine detail included in these places of worship, such as the Notre Dame Cathedral show that art and design was very much appreciated. During the time of the Roman Empire, soldiers protected the middle and lower classes until it fell. The law then no longer protected the individuals, so they turned to the Lords to keep peace and protection. Thus began a period of time called the middle ages and the start of feudalism, which existed for over a century.Everyone's life was lived out against a backdrop of fear; fear of violence, bloodshed, brutality, fear of starvation, fear of dying, and fear of ones fate in the afterlife. Famine and sickness were major factors in death during this time, considering they depended on ropes and agriculture to prosper, and the cold climate led to less food on their plates and nothing to sell at the market. Even when food was abundant, serfs still lacked a dependable source of essential vitamins, leaving them weak and vulnerable to death.Their water was polluted and there were no sanitation systems, which often led to epidemics. They lived in hovels that were poorly wood constructed shelters that had no indoor heating; no windows to bring in natural light and generally caught fire. (Cantor, page 383) Their only defense against living in these harsh environments was elision; faith in God was their only hope for salvation in the after lif e. People also believed when misfortune struck, whether in the form of fire, drought, famine, and war, that they had failed God. Constantine the Great was considered to be the last great emperor of Rome.Although his reign was before the middle ages, he played an important transitional role in history through his recognition of Christianity, which became the prominent religion in Europe until the Reformation. Due to the fact that civilization survived in such harsh living conditions, the Christian faith brought everyone together in a more positive light and shaped their lives from birth to death; their purpose on earth was to serve god, who was above them. Humanism wouldn't make its presence known until the beginning of the renaissance, which was not until a century later, and society was Just adhering to the norm.Following the norm gave them great security, physically and emotionally. In any society that thrived for protection from the harshness of life through religion, people look ed to however could secure your happiness in heaven; this person had the most political and cultural power. The Roman Catholic church was the supreme power during the Middle ages, and the laws of the land and leading roles of government were all in the hands of church leaders such as bishops and archbishops. The Pope was considered the most powerful, as he was God's representative on earth.Although priests and kings had their individual responsibilities from the church, priests had a commitment to God, to communicate with him on behalf of the people, handing down Gods rules of conduct, where as the King was responsible for the people to adhere to those rules of conduct; he was noninsured God's Solider. The king had lords and nobles who served him, controlling the land in exchange for protection of the serfs, villains or peasants. To maintain such an operation, one might have as many as 500 serfs in his household, while those lower on the social scale might have an average of 70.Sinc e the church had extensive land holdings, it had great leverage in structuring feudalism (Blackmore, Robbie, page 68). The definition of feudalism is, ââ¬Å"A political and economic system of Europe, based on the holding of all land in fief or fee and the resulting relation of rod to vassal and characterized by homage, legal and military service of tenants, and forfeiture. â⬠(Cantor, page 164) Feudalism is known for its negative connotation; however, it still gave people a reason for salvation, and aided in their interest in a higher existence.Feudalism put fear in society's eyes, yet funded the construction of the cathedrals, which ironically had the opposite effect. Cathedrals were one response to the unsettling conditions of such a feudal society, but also became powerful and emotional masterpieces bringing the image of heaven to earth. These places of worship would serve to the lower classes and became city landmarks, a place where the village could experience solidarity. Together cathedrals and the cities they resided in would prosper. Having centered themselves in the heart of the town, places of worship brought people from the countryside to the center of the city (Scott, page 69). Unlike the more classical based architecture that came before it, the Romanesque style, Gothic architecture was built with excess. The Gothic characteristics strove for extreme proportions and dimensions; this created new structures to heighten the buildings, as well as improving window sizes to bring in enough light. Gothic architecture had wider windows and doors than those of Romanesque buildings.According to their understanding, ââ¬Å"light is a substance, yet it differs from other substances through its ability to penetrate glass or precious stone without splitting themâ⬠(Hovercrafts, page 51). The flying buttresses, pointed arches, ribbed vaults, soaring ceilings, and stained glass windows characterize gothic design, making it functional, yet dramatically appealing. They clearly understood the importance of light, and how bringing that element into the building changed people's perceptions and attitudes. Notre Dame Cathedral is one of, if not the most profound example of gothic architecture.Construction of Notre Dame began under the direction of Maurice De Sully, Bishop of Paris in 1163. Geometric proportioning was fundamental for gothic design, which also led to the flying buttresses. When Notre Dame started its construction the walls were so thin, that arches on the exterior had to support the vertical and narrow proportions. The flying buttresses were not originally exposed and didn't become acceptable until the end of the 12th Century. Cathedrals during this time were competing to be the tallest, which symbolized wealth and power (Scott, peg 94). Geometric proportion was indeed a constant preoccupation in the middle ages,â⬠(Gridlock, page 14) and this created a whole new style for the nave and an increase in the size of the stain glass windows. This cathedral's high alter was consecrated in 1189, and the nave was finished around 1196. The west faded of Notre Dame was completed between 1225 and 1230. The west faded displays an important characteristic to the gothic style, the rose window, which has many efferent conceptions on its significance.Relating back to the Romans and the culls centered upon the Pantheon in Greece, some view it as the symbol of the sun, and God, also as its original form a flower which represents Mary, and lastly, heavenly Jerusalem, which is known to be a round city (Hovercrafts peg 50). Not only did the window symbolize god, but also the shape of the building as well, The Latin Cross was the architectural shape of the building, as if God was looking down from heaven recognizing their faith. The towers topping the west faded were completed around 1250.It took over 200 ears to complete, taking into consideration the climate, need for materials and transportation, labor, and warf are. A tremendous amount of effort implies the importance the cathedral had to the population. Abbot Surer believed, ââ¬Å"everything that is most precious should be used above all to celebrateâ⬠. Abbot Surer was an influential leader during his time and patron of the arts. He was a classmate and friend to the future King Louis VI, who later appointed him Abbot of church Saint-Denis (Cantor, page 398 ).His duty was to enhance the stature of the church Saint-Denis, and under his power the church was renovated so rustically that it has become the first example of the Gothic style also known as the ââ¬Å"heavenly capitalâ⬠. Light was the primary source of faith and divine inspiration, opening up the dark Romanesque walls and cramming it with aisles and replacing the clerestory windows with stained glass. Stained glass is another important element to the cathedral's design; one of the oldest surviving stained glass windows dates back to 1065, and can be found in the Cathedra l of Sagebrush in Germany. (Cantor, page 397) www. Sobs. Rag Popular designs depicted scenes from the bible as well as the lives of the Saints. Some also illustrated everyday life, showing Artisans at work. Romanesque cathedrals had such thick walls and small windows, they provided poor light, whereas Gothic cathedrals had windows so large that the stained glass would lay out on an entire floor. Understanding that light symbolized God, as the light came through the colored glass, often gave individuals a feeling of intense spirituality, not only illuminating the church, but them as well. Since few people could read or write, the windows also gave them a source of religious instruction.Sculptures were used as well throughout dihedral history. Sculptures of little monsters called Gargoyles conveyed more then one message, primarily to instill fear into the city. These Gargoyles represented the evil on earth, but were also said to scare off evil spirits, assuring citizens that it was a holy place. (Cantor, page 397) Ornamentation throughout the middle ages gave people an understanding to life and glorifying god. Over 80 cathedrals, and 500 abbey churches were built in the gothic style, (Cantor, page 104) astonishing monuments of Gods glory, each remained intact until the reformation.Cathedrals didn't build over night, like today with skyscrapers that take six years to build. It took up too two hundred years, some generations wouldn't even get to see them completed although worked on them their whole life. Workers would use the most basic tools, and the number of tools required for such a task were quite small, for example hammer, epic and axe, saw; working in conditions that modern day health and safety laws would forbid today. (Scott, page 21) It clearly shows the importance of these building to the people during that time period.Everything about he medieval cathedral, special use of light, layout, and sculptors are all inspirations of God. People feared that fai lure to use the best human creativity might be interpreted by the God as something less than full devotion, so they felt compelled to use all of their artistic, engineering and craft based creative individuals to create the finest space they were capable to build. Architecture was their doorway to a better life and as evidence shows the monumental cathedrals and churches built during the early Middle Ages were cherished art and design.
Thursday, August 29, 2019
A Brief Note On The Vietnam War Of Vietnam
Vietnam War On November 1, 1995 the North Vietnamese attacked South Vietnam to mark the beginning of the Vietnam War (Tet Offensive). Spanning nineteen years, the Vietnam War was a conflict fought between six different countries and allies over the differing opinions concerning communism. Ho Chi Minh was the leader for the North and believed in a communist government and received help from the Soviet Union and China (Biography of Ho Chi Minh). On the other hand, leader of Southern Vietnam, Generalâ⬠¦ The Vietnam War was an extensive and expensive war between the Communist regime of North Vietnam and South Vietnam, known as Viet Cong. The United States were allies with South Vietnam. Ho Chi Minh was the founder of the Indochina Communist Party and the prime minister and leader of North Vietnam. His Communist party was called the Viet Minh. Ngo Dinh Diem was the first President of South Vietnam. He was not in favor of Communism. The war started on November 1, 1955 and ended on April 30, 1975.â⬠¦ How To Do Business In Vietnam Name: Institution: How to do business in Vietnam Background Vietnam is a Southeast Asia country bordering China to the north, Cambodia and Laos to the west. The country has a population of 90.5 million residents. Hanoi is the capital of Vietnam but Ho Chi Minh City in the south is the most populated and the largest commercial city. The coastline opens up to the Gulf of Thailand. The land area of Vietnam is 331,114 square kilometers. A largeâ⬠¦ the early days of the Vietnam war, United states involvement was limited to training and assistance to the South Vietnamese to help them defeat the communist soldiers of North Vietnam. The Vietnam War was a military conflict fought between North Vietnam and South Vietnam. South Vietnam was supported by the United States and other anti-communist allies; whereas, the North Vietnamese were supported by their communist allies. The Viet Cong fought using a guerrilla style of war, ambushing in small troopsâ⬠¦ The country of Vietnam has always been in some sort of disputation. Previous to the Vietnam war, Vietnam was continually on the brink of losing their country to the French. From 1874 to 1954, the French colonization of Vietnam was taking place. After the French conquered Vietnam, they had goals including profiting economically, teaching and spreading the history and language of French culture, and having total dominance over Vietnam. If an individual was Vietnamese at this time they had the choiceâ⬠¦ Vietnam war was started 12 years just after WW2 had ended. Vietnam war had started because of the struggle between the republic of Vietnam. You had 2 parts of vietnam who couldn 't get along and agree so they made a Line along the 17th Parallel call The Demilitarized Zone. It had separated North Vietnam and South Vietnam. The north was always meaner and the bad country while South vietnam was the nicer and gooder country. The Capital of North Vietnam was Hanoi. The capital of South Vietnam was Saigonâ⬠¦ psychologically by a history of war. After the Vietnam War, the country crippled under the leadership of the Communist party, the dominant and only political party in the country. The Communist party spreaded its control over every aspect of the countryââ¬â¢s citizens and, at the same time, created a pseudo democratic system. The main cause of such corruption is the connection between the Communist Parties of Vietnam and China. While there exists a psychological border between China and Vietnam that has been aroundâ⬠¦ maintain control over their Indochinese colonies. Lastly, the United States would get involved in Vietnam in an attempt to prop up the southern Republic of Vietnam against the communist Democratic Republic of Vietnam. The following will be a brief summary that compares and contrasts the French and American conflicts in Vietnam by looking at motives for the wars, how the territorial boundaries of the war were defined, differences in understanding of why the Vietnamese wanted independence, and if theâ⬠¦ The Vietnam Conflict The Vietnam War, also known as the second Indochina war was fought between the years of 1954 and 1973. Although the American involvement was not as concentrated until 1963. The record for longest war in American history to this day goes to the Vietnam, but the story doesnââ¬â¢t start when America stepped in, it goes way beyond that. Before either of the Indochina wars, Vietnam was a French Colony. The French maintained strong control of Vietnam until the Japanese invaded duringâ⬠¦ The war in Vietnam lasted for nearly 10 years and took a toll on both the American and Vietnamese people. The war in Vietnam produced large numbers of casualties and a rapid loss of support from the American people. The American leadership, both in Washington D.C. and on the ground had a lot of responsibility for the outcome. This is a piece of history that we donââ¬â¢t want to repeat in the future. This paper will prove that the Vietnam War was almost impossible to win and caused great loss and sufferingâ⬠¦
Wednesday, August 28, 2019
English SLP 5 Essay Example | Topics and Well Written Essays - 1000 words
English SLP 5 - Essay Example Following are the highlights of my related skills and qualification: BE Mechanics. MBA Operations Management. 7 years of experience in textile industry where my core job responsibilities were to maintain production plants, analysis of production reports and procurement of new machinery. 5 years of experience in cement industry where I joined as an operations manager. Here my basic responsibility was to look after the existing facility. I have been concerned about location design, selection and maintenance of facility as part of my current job. Operations managers are critically required to assist all the business activities while ensuring the smooth flow of input, process and output (Greasley, 2008). As per the requirement of United States Steel Corporation, I possess sound understanding of location management and hence I will prove beneficial for your organization in terms of future strategic decisions and facility planning. Effective and efficient planning is the core component of achieving competitive advantage because it outlines the fundamental goals and objectives while giving an execution procedure to the company (Arnold, et. al., 2011). I have good communication skills which are essential for managers. Moreover, I can perform exceptionally well in terms of generating electronic reports and analyzing data. Computer skills including preparation of data sheets, online research and data interpretation are the sole responsibilities of an operations manager at US Steel Mill and I can surely perform well on all these job related tasks. Professionally I am very flexible and available to work at different schedules. The operations manager is required to perform distinctive job responsibilities and I can effectively manage different tasks simultaneously. Hence I will prove productive for the organization due to my huge experience in different industries and also because of my critical thinking and quick analysis. I can efficiently meet short deadlines without com promising on the quality of work. Moreover, I can coordinate with other departments including sales, marketing, human resource, finance, accounting etc. In addition to this I work with due consideration to the ethical code of conduct while refraining from breach of law. This can be further verified from my enclosed certificates and awards received from my past experience. I can surely benefit the organization in different ways while maintaining its prestige and reputation in society. I am looking forward to serve you through all possible ways while utilizing my skills and abilities. Enclosed is my resume for your consideration. Sincerely, [Name] E-mail to Mother Dear Mom, I am excited to inform you that United States Steel Corporation is now offering a vacancy in operations department. It was my dream to serve the US steel mill as an operations manager and hence I immediately sent my resume and all other related documents. The Human Resource Manager has called me for an interview on this Friday at the Steel Mill Headquarters and therefore I will leave today by the evening. Although my dream is about to get fulfilled yet I am worried about your response because after shifting there I would not be able to meet you every Sunday nor I would be able to have random conversions with others at home. Surely I will miss the precious family time we spend together.
Tuesday, August 27, 2019
Medieval Romantic Literature Essay Example | Topics and Well Written Essays - 2500 words
Medieval Romantic Literature - Essay Example It is worth noting that, despite the superficial portrayal of an ideal world, these stories reveal a bi9g deal of realistic problems that come to humanity. "Wife of Bathââ¬â¢s Tale" This narrative belongs to King Arthurââ¬â¢s category. The narrator of the tale is the wife of Bath. She tells the story of knight who followed the habits of incubi that existed in the preceding era. The story highlights the consequences that befell one of king Arthurââ¬â¢s knights after he gave in to his fleshly desires. The knight committed rape, an offense that had terrible effects. The knight had come across a maiden who had irresistible beauty1. The knight could not suppress his desire and he decided to use the power bestowed upon a knight and forced the maiden into the ordeal. In those days, knights were real warriors accorded respect and honor by the subjects of the king. However, soon the king came to knowledge of what he had done. The knight had miscalculated his chances of getting away w ith the crime he had committed2. King Arthur did not intend to spare him from the decapitation that awaited him because of his act. However, the queen made a suggestion to the king. She intended to save the knightââ¬â¢s life. However, she demanded that the knight had to indulge in interviews and provide an answer the inquiry that queen would pose. The queen ordered the knight to find out what women desired most. His life would be safe if he established the right answer to the inquiry. However, if his venture proved a failure, he would face decapitation. The knight embarked on a journey to different parts of the land seeking to establish the one desire that a woman would do anything to have fulfilled. For some time, his venture was proving unsuccessful because different women had varying answers for his inquiry3. However, knowing that finding the real answer was fundamental to saving his life, he did not give up but on with the search. In the end, he found an old woman, who offere d to help him out. However, the woman was not pleasing to the eye for she was ugly and old. She offered to help but with conditions. She demanded a pledge from the knight. The knight, knowing that he had a few days left before he presented himself before the queen to provide an answer to her inquiry; he gave in to the demands of the old woman. He promised to commit himself to the old woman4. The old woman provided him with an answer that impressed the queen, saving his life. However, the knight found it hard to live up to his pledges to the old woman who gave him the right answer. However, he was indebted to her and had to marry her. However, after the marriage, it was difficult for him to accept that he going to live the rest of his life with the wretched woman. On realizing his state of unhappiness and displeasure, the old women inquire why the knight was in this state. The knight explained that it was hard to accept the reality he was facing. The old woman gave the knight two opt ions to choose. On one side, the knight was to decide whether if he preferred a beautiful, but unfaithful wife or he wanted her to remain ugly but loyal. At this point, the knight put into application the useful information that he had gathered from the queenââ¬â¢s inquiry. Realizing that a womanââ¬â¢s greatest desire is having her man under her control, he gave her the freedom to choose what she preferred to become to her man. Fortunately, it worked for him because the freedom to choose presented her with an opportunity to feel superior to
Monday, August 26, 2019
Does Alcohol dependancy lead to depression Essay
Does Alcohol dependancy lead to depression - Essay Example cancers, unintentional injuries, and violence.â⬠(Mokdad, Marks, Stroup & Gerberding 2000) Professional health care practitioners are constantly vigilant on monitoring alcohol dependents, especially if it exists in conjunction with other illnesses, like depression. The negative effects that alcoholism causes cannot be undermined. This paper is written to present a review of literature on the topic: does alcohol dependency lead to depression? Given the research question, the purpose of the study is to explore four scholarly researches made on the topic identifying methodologies, findings and general consensus. The U.S. Department of Health and Human Services define alcoholism, also known as ââ¬Å"alcohol dependence,â⬠as ââ¬Å"a disease that includes four symptoms: craving: a strong need, or compulsion, to drink; loss of control: The inability to limit oneââ¬â¢s drinking on any given occasion; physical dependence: Withdrawal symptoms, such as nausea, sweating, shakiness, and anxiety, occur when alcohol use is stopped after a period of heavy drinking; and tolerance: The need to drink greater amounts of alcohol in order to ââ¬Å"get high.â⬠(2001, 1) ââ¬Å"The American Medical Association and the World Health Organization have both recognized addiction (including alcoholism) as an illness, not a lack of willpowerâ⬠. (Dossey, Keegan, & Guzzetta, 2000, 514). Definitely, this is a fact that pervades people from all walks of life depending on diverse factors. According to Dossey, et.al. (2000), ââ¬Å"although there are many types of addictions to various substances, alcohol addiction is the most prevalent in the United States, afflicting at least 11 million peopleâ⬠. (514) There are a multitude of scholarly researches written on alcoholism and diverse concerns related to it. Through secondary sources from books, journals and electronic references, appropriate materials would enable one to proffer a comprehensive and objective view of the topic. A study conducted by Dr. Achal
Sunday, August 25, 2019
The Rights of Women and the Rights of Humans Essay
The Rights of Women and the Rights of Humans - Essay Example According to the study the rights of women are violated through domestic violence such as battering meted at them, sexual discrimination, workplace discrimination on the basis of their genders, decision making in the political processes and many other areas. There are also cultural practices which discriminate unfairly against such as genital mutilation, poor nutrition and denial of education for the girl child in some communities. All these are atrocities directly faced by women on a daily basis but the dilemma both historically and conceptually is how to separate them from human rights. It becomes difficult because women just like men are humans and the question of human rights is invoked there is no differentiation between women and women. This essay highlights that it is very important for every person to realize that there is a difference between gender equality and human rights. In my opinion historical injustices that continue to be committed against women such as rape and denial of the right to education not only amount to violation of their rights as women but as humans. Many nations around the world have made deliberate efforts in terms of policy to educate their citizenry on the importance of treating women as equals with their male counterparts and abandon negative cultural practices such genital mutilation which negatively affect the lives of women. But the practices continue to happen on a daily basis, rape continues to happen, mutilation and denial of quality education continues in some communities.
GLOBAL IMPACT Essay Example | Topics and Well Written Essays - 1250 words
GLOBAL IMPACT - Essay Example These segments include the US, Europe, Asia-Pacific region, Middle East, Africa, Canada, and Latin America (McDonalds, 2014). Thus, tourists to other nations, as well as within a country can procure McDonaldââ¬â¢s products in a number of locations. In the year 1948, the first McDonaldââ¬â¢s was commenced in San Bernardino, California. The owners Mac and Dick McDonald entered into a franchise agreement with Ray Kroc, in the year 1954. After a year had elapsed, Kroc started his first restaurant in Des Plaines, Illinois. Kroc proved to be highly enterprising, and by the year 1957, he established 14 McDonaldââ¬â¢s restaurants in California, Indiana, and Illinois. Finally, in the year 1961, Kroc acquired McDonaldââ¬â¢s from Dick and Mac for $2.7 million (Research and Markets: SWOT & PEST Analysis of McDonalds and Profiles of their Competitors Burger King and Yum!, 2008). Additionally, McDonaldââ¬â¢s is distinguished by its Golden Arches, and these made their debut in the year 1962. In the very same year, this distinguished company sold its billionth burger. In the year 1963, Ronald McDonald came to the fore, and McDonaldââ¬â¢s brought in its first new item, namely the Filet-O-Fish. This company became a public company in the year 1965, and commenced to advertize its products on the television. In the year 1967, McDonaldââ¬â¢s commenced operations abroad, and this was in Canada. The Big Mac was made a part of its menu, in the year 1968, and in that year it opened its 1,000th restaurant (Research and Markets: SWOT & PEST Analysis of McDonalds and Profiles of their Competitors Burger King and Yum!, 2008). The Big Mac and the McDonaldââ¬â¢s Golden Arches are well recognized across the globe. Their services offer delicious fast food items and soft drinks to the populace. The annual expansion of McDonaldââ¬â¢s, in the 1970s, was approximately 500 restaurants. The advent of the Ronald McDonald House, which provided temporary residence
Saturday, August 24, 2019
Should state legislatures be removed from the redistricting process Essay
Should state legislatures be removed from the redistricting process for congress and their own seats and would doing so improve - Essay Example In the US, redistricting is fundamentally political because legislators are responsible to draw electoral districts in many states. Courts have been intervening in the process to a great extent. These aspects of redistricting are inter-related and have made the process highly controversial because the outcomes are mostly prejudiced in favoring one political party over another. Redistricting matters a lot because peopleââ¬â¢s representatives in the state and federal governments frame regulations, which impact several issues such as taxes, security, prices and the environment in which people live. This paper will examine whether state legislatures should be removed from the redistricting process for Congress and whether doing so will improve the public policy process. Main Body Elections are held at regular intervals in ensuring that peopleââ¬â¢s representatives work towards welfare activities. All state legislators and many legislators in the Congress represent districts that pa rtition states and voters into geographical regions. In majority districts, voters are eventually represented by legislators that win the maximum votes. The manner in which voters are assembled into districts has a strong bearing on the people that will represent them and the kind of policies they will follow. For instance, a district comprising mainly of farmers will, in all probability elect a legislator who will work towards their cause. But a district that comprises of mainly urban citizens would in all probability elect a person who has different concerns. In similar vein, regions characterized with groups of similar language, ethnicity, race and political lineage will probably elect a person with similar characteristics. Therefore, the manner in which the districts are created can impact the constitution of the legislature. It is thus apparent that there would be different legislators if the districts are drawn in different ways. The process of redistricting mostly draws a lot of attention and controversies are created because the process determines the communities that will be represented and the laws that will be made (Griffith, 2011). Redistricting is resorted to in the United States in reacting to change in populations that are determined by the outcomes of the census. The state legislature is vested with the authority to create redistricting plans that are in some cases subject to the governorââ¬â¢s approval. Every state in the US has its own law and constitutional requirements to redistrict. There are some aspects of the law concerning the federal government that have been introduced following decisions by the US Supreme Court. The Congress established the Voting Rights Act in 1965 that was amended in 1982. The Congress also exerts some control in the context of putting restrictions on the creation of electoral boundaries during the redistricting process. The courts in the US have played a major role in developing and interpreting redistricting laws. Essentially, a redistricting plan should create districts that have a balanced population and should not reduce the say of minority voters. In order to improve upon the public policy process, the redistricting plan should give credence to conventional redistricting issues such as contiguity, density and respect towards political subdivisions and communities (Canon, 1999). According to Halper and Simon (2011), removing state
Friday, August 23, 2019
EVIDENCE BASED PRACTICE Assignment Example | Topics and Well Written Essays - 1500 words
EVIDENCE BASED PRACTICE - Assignment Example This paper discusses the strengths and the weakness of the evidence-based method. This paper also discusses the future and current state of clinical guidelines and the limitations of the guidelines as well. Evidence-based medicine is about solving clinical problems, it does this through a process of bringing together the best evidence of clinical experience and patient values. Clinical efficacy is a critical assessment of anything you do which is aimed at making a change in practice as a result of having a positive outcome. The main purpose is to improve patient and care experience. Clinical effectiveness measures outcomes on an individual patient level. Clinical effectiveness studies help healthcare professionals to understand how to design treatments based on patient variation rather than cost. Clinical effectiveness is about the right people, doing the right thing, the right way, in the right place, at the right time with the right result (Graham 1996). In the context of my practice as aà podiatrist, the right person would primarily be well-trained and a member of the Health and Care Professions Council (HCPC), with knowledge of the new advances in podiatry, such as local anaesthesia, nail surgery, diabetic feet and gait analysis. All the above specialities need extended training such as Continuing Professional Development. Clinical effectiveness doing the right thing is aimed at making clinical practice more accurately based on the use of investigations that have been proven to be effective relative to the specific patient needs (Graham 1996). To do things in the right way it is necessary to have a well-trained and competent work-force that has clear responsibilities and works together in this new era of podiatry to deliver the best value healthcare possible. The right result refers to the maximization of health effects,
Thursday, August 22, 2019
Argue the case for and against Globalisation Essay Example for Free
Argue the case for and against Globalisation Essay This essay will concentrate on the factors of Globalisation and the effects it has on the world. Globalisation can be defined as something which has become spread across the globe. This includes all manner of objects such as people, money, technology and even ideas. The concept of globalisation has been going on for many centuries but it is only in recent years that it has become a major issue. The Roman Empire was a global society as the Romans ruled much of the known world. They used colonialism as an economic process in order to globalise themselves. From these colonised areas they obtained goods and raw materials which they could ship across the world. This still happens to this day and people also migrate causing multicultural countries. Cultural forms start to cross and become global forms. An example of this is sport. Many countries will play the same sport and even compete against each other. This was shown in the recent Commonwealth Games in Manchester. Cultures can be spread even through art and fiction. Novels and stories representing different peoples lives and experiences are read throughout the world spreading these cultures. In the process of Globalisation it is Decolonisation that takes place. In the past century many countries have gained independence. We now live in a new world order. Arjun Appadurai explains about Globalisation in the article Modernity at Large which is found on the website listed in the Bibliography. Appadurai has studied globalisation and has named a number of global flows. He describes the different ways in which Globalisation takes place. Ethnoscapes is the flow of people going around the world, for example tourism. It can also be seen when people migrate and is evident in modern society with refugees and asylum seekers. Trans-national class people are business and homogenous people who determine things like fashion and music. One of the most global items is money. Appadurai defines this as Financescapes. People send money across the world for their relatives and to pay for goods they have bought from a different country. There are many different ways for money to be transferred around the world, some are legitimate but there are also illegal ways such as drugs, arms and porn industries. These industries send vast amounts of money all over the world. The other big industry is that of Technology Technoscapes. In todays electronic age it is easier than ever for information to be moved from one place to another. The Internet, computers, mobile phones and other such electronic devices all provide consumers with the easiest form of the transferral of technology. Commodities around the world are becoming global. Products like Coca-cola, McDonalds, Microsoft and Nokia are now all recognised around the world. It is estimated that in 1990 the one hundred biggest transnational corporations produced 50% of the worlds output. So it is clear that globalisation is more than ever present in the modern world. All the above factors contribute to the increasing global nature of our society. However, what does all of it really mean? Does the fact that Globalisation is increasing result in the world getting better or worse? In order to answer these questions we must examine the benefits and disadvantages of living in a global culture. As mentioned before, one beneficial aspect of Globalisation is that of technology. Technological advances have resulted in the improved lives for millions of people around the world. This improvement was not restricted to just individuals but to communities, groups and even to the extent of countries at large. It cannot be denied that Globalisation has benefited businesses and companies in respect to technology and their target audience. However, some would argue that this mass technological advancement could lead to a lack in privacy. With the Internet in thousands of homes and with almost any kind of information available on it, some people feel that their privacy is invaded. Is Big Brother really looking at us at every opportunity? An obvious advantage of globalisation is that it brings together many different countries. The best example is probably the United Nations or the UN. This is a collection of some of the worlds most powerful countries and they have come together to become, arguably, the most powerful force on the planet. They are, however, a peaceful organisation who tries to uphold international laws. Perhaps one of the first steps to Globalisation was to name the different continents. This automatically places countries into groups and they can all be referred to by one name, for example Europe or Africa. Does this mean that everything is going to be the same? If the different countries are becoming recognised as one large continent then does it result in these countries being the same themselves? There isnt this much of lack of diversity. Globalisation may be more than ever present but every country has its own history, culture and way of living. This creates and upholds diversity in all countries. The immigration and emigration of people causes cultures and communities to spread all over the world which is another way of diversity being created. There are two main theories of the world. The first says that the world is becoming more American where as the second suggests that the world is becoming more diverse. The world being similar is known as homogeneity and the contrasting view of diversity is referred to as heterogeneity. So to conclude, it is clear that the world is becoming more and more globalised, especially in recent years. Globalisation is a man made feature of our world and it is unlikely that it will stop or even slow down in the foreseeable future. It does have a number of advantages and disadvantages, some of which highlighted in this essay. Globalisation may lead to a compression of the world and an intensification of consequences of the world as a whole but the benefits must surely outweigh the bad points as otherwise it would not have existed as long as it has. One thing this essay has concluded from researching the issue of Globalisation is that the world is so big and yet so small at the same time. We now live in a global village Marshall McLuhan. Bibliography R. Robertson, 1992 Globalisation N. Abercrombie A. Warde Contemporary British Society D. Cooper Power in struggle
Wednesday, August 21, 2019
Reverse phase High Pressure Liquid Chromatography for measuring hydrolysis of ester Essay Example for Free
Reverse phase High Pressure Liquid Chromatography for measuring hydrolysis of ester Essay Reverse-Phase High performance chromatography consists of any method of chromatography that utilizes a non-polar phase. In the early part of 1970s, non-modofied alumina or silica which has a greater attraction for polar elements and hydrophilic surface chemistry was used for majority of the liquid chromatography. Because of this, this method was said to be normalâ⬠. The elution order was however reversed with the introduction of a covalently bonded alkyl chain which reinforces the surface. In this method, the first to be eluted are the polar compounds while there is retention of the non-polar compounds hence the procedure is termed reversed phase Method validation Itââ¬â¢s important to validate all various HPLC methods. Evaluation of suitability may not be necessary when methods from pharmacopoeiaââ¬â¢s are utilizes given that the analyses are carried out with respect to the techniqueââ¬â¢s intended use. However, in situation where drug composition is being modified, a reevaluation of suitability of the HPLC method to its new intended use is necessary (Nagels etal, 2002). The variables tested in the validation process as stated by FDA, ICH and USP as well as other health bodies include: Accuracy, linearity, limit of quantitation, limit of detection specificity relativity, reproducibility precision which includes repeatability, intermediate precision as well as ruggedness/reproducibility (Amersham, 1999). Role of rp-HPLC method for the measuring hydrolysis of ester Reverse phase high pressure liquid chromatography can be used in separation quantitation of free fatty acids as well as its methyl esters obtained from tissue phosphopids of mineral. In this method, mixtures of water acetonitrile are utilized for elution of esters. For free acids to separate, aqueous phosphoric acid substitute for water. Quantification detection of unsaturated compounds are done by absorption at 192nm . After methyl esters have been prefractionated based on its unsaturation by argentation TLC, there is total rapid separation by elution with CH3CN. Reverse phase HPLC can both be applied as preparative analytic method as well as in biochemical separation and purification. Precision In rp-HPLC, precision is assessed by injection of several standards followed by measurement of the variability of the results. Three subcategories are obtained from the measured standard deviation . To assess repeatability, the operator executes the analysis in a laboratory over a short period of time. Then, the relative standard deviation is calculated from 5 or 6 determinates of two dissimilar matrices at 1 or 2 different concentrations. The ICH describes intermediate precision as long term variability this is estimated by comparison of several results of a single laboratory over several weeks. Variations of results gotten by different instruments, different batches of column and from operators with materials from dissimilar supplies are reflected in intermediate precision (Amersham, 1999) It is important to validate intermediate precision in rp-HPLC so that verification of same results being produced by same method in same laboratory following the phase of development could be possible. Reproducibility otherwise called ruggedness is simply inter-laboratory precision . Itââ¬â¢s aim is to ensure that different laboratories will have same results using the method. Variables that affect the reproducibility of rp-HPLC include the varying operator experience, varying ages of equipment, differential supplies of columns, variation in humidity room temperature, different characteristics of equipment such as the delay capacity of HPLC system (Lebendiker, 2006). Accuracy is the degree in which test outcomes are proximate to the true value. This is obtained from outcome of quantitative assessment of a known sample. Whatever is measured is then compared to the known amount. Selectivity specificity These are usually interchanged . Selectivity of analytical method like rp-HPLC refers to its capability despite the presence of interference, to still be able to measure accurately (Guzzetta, 2010). Such interference includes enantiomers, degradation products and excipients. When selectivity of a method is verified, it becomes ââ¬Å"Stability Indicating Methodâ⬠. Limit of detection This refers to the least amount or concentration of analyte in a chromatographic sample that may not be quantifiable but is detectable. In rp-HPLC, the limit of detection is that amount which after injected gives a maximum height of 2 to 3 times as raised as the reference noise level. Limit of quantitation refers to the least amount injected that results in precise measurement. In rp-HPLC, maximum heights of about ten to twenty times greater than reference noise are usually required at precision of less than 10-15% RSD between intervals of results. Linearity With injection of three to five series of four or more standards with spanning concentration of 80-120% expected range, the linearity of a rp-HPLC analytical method can be determined (Amersham, 1999). Whether directly or by calculation, it is expected that the response should be in proportion to the analytesââ¬â¢ concentration. The intercept of linear regression formula applied to these results should not substantially differ from zero. An intercept of significant non-zero should be followed by validation that there is no impact on method accuracy (Alveldano etal, 2010). Principle This operates of the separation of substances based on hydrophobic binding between the stationary/immobile hydrophobic ligand (called the stationary phase) and the solute in the mobile phase (Amersham, 1999). The binding interaction is presumed to be due to favorable entropy effect. The original mobile phase conditions in rp-HPLC are aqueous implying a highly organized water structure around stationary ligand solute molecule . The available area exposed to solvent becomes diminished with binding of solute to the stationary hydrophobic ligand. With this, there is decrease in organization of water structure increase system entropy (Amersham, 1999). In summary, rp-HPLC is based on ââ¬Å"adsorption of hydrophobic molecules onto a hydrophobic solid support in a polar mobile phaseâ⬠. Reverse phase HPLC has also been utilized in most analytical methods.
Tuesday, August 20, 2019
The Use Of Ict In The Airline Industry Tourism Essay
The Use Of Ict In The Airline Industry Tourism Essay Abstract This essay throws light on the use of ICT in the airline industry and what impacts developments in ICT have made on the said industry. The essay highlights the role of ICTs in enhancing airlines capability to interact with customers, reducing the operational costs, increasing the convenience for making reservations, managing air traffic, administering the crew and airport staff, improving the passengers in-flight experience, maximizing airlines revenue by variable fares, improving security standards, promoting partnerships and alliances among airlines, integrating value added services. It has been argued that automation increases efficiency but human factor is yet very important in personifying the customer experience. Introduction to the Airline Industry An airline provides air transport services for passengers and/or freight. Commercial operations of airlines date back to early 1900s, however, evidence of increase in operations is found after World War I. Over the years, airline as an industry has grown tremendously. It has facilitated economic growth, world trade, foreign investment, tourism and has played a significant role in globalization of industries. Full-service airlines have a high level of fixed and operating costs in order to establish and maintain air services: labor, fuel, airplanes, engines, spares and parts, IT services and networks, airport equipment, airport handling services, sales distribution, catering, training,Ã aviation insurance etc. Keeping in view such high costs and complex nature of operations, it is essential for airline companies to take advantage of ICTs to carry out operations smoothly and optimize expenses. Use of ICT in the Airline Industry Technology is dramatically and profoundly changing the nature of services. Technology is also profoundly changing how services are delivered, and it is enabling both customers and employees to get and provide better, more efficient, customized services. These changes have significant implications for managing service operations as well as for predicting and managing consumer behavior. Impact of Developments of ICT on Operations of Airline Industry In the text below, major operations of the airline and airports have been discussed. It has been analyzed that how the developments in the ICT have impacted the processes of the said industry. The developments in the ICT have significantly influenced the way Airlines interact with customer, develop loyalty programmes and implement customer retention strategies. Few developments to enhance the passengers in-flight experience have also been made. Interaction with Customers The proliferation of internet and World Wide Web has made it enormously convenient for the organizations to interact with their customers. Internet has provided a very economical way of interacting with customers, has reduced distribution costs, and has increased the profit margin by direct selling. Internet has also served as a purveyor of information about travel. Carriers everywhere have embraced online ticket sales as a means of reducing distribution costs. Travelers now have the opportunity and convenience to compare price and service offerings of all airlines quickly and efficiently, and to act on those comparisons instantly with only a few keystrokes. McIvor et al. (2003), present analysis of four airline companies and their use of internet to provide innovative interaction and transactional mechanisms with customers. They state that internet has increased the expectations of customers for the services and service delivery. In fact, the internet has become essential to the strategic development of the airline companies. They further argue that the scope and boundaries of the airline industry have become less clear as a result of the adoption of internet technologies at the customer interface. The offering of a range of products and services is creating industry convergence. Exploitation of the internet at the customer interface has become a key catalyst in the transformation of the airline industry. In the past, airlines have been selling their product (i.e. an airline seat) through travel agents. The travel agents competitive position was based on exploiting the information insufficiency at the customer end. However, nowadays, the website of the Airline makes customer autonomous to decide on the fares, routes and various services associated. The internet enables airlines to build a direct and superior relationship with customers. In this era, the airlines site support complete automation of the booking process and limits the need for human intervention. Airlines are extensively investing and utilizing the Internet to further undermine the travel agents which has also resulted in improved process efficiency. Furthermore, removal of the travel agent layer has reduced transaction costs and has enhanced the relationship with customer through the provision of more detailed and up-to-date information. Customer Retention and Airline Loyalty Programmes The cost of developing a new customer is several times higher than the cost of keeping an existing customer. With the increasingly fierce market competition, companies would like to retain their existing customers as much as possible. Fan (2007), state that competition has changed gradually from price of products and services to grasping customers. Only those companies that can more precisely understand customers demands, more quickly respond to the changing needs and can improve customer satisfaction and loyalty can win the competition. Customer Relationship Management (CRM) has become particularly important in this age. Data mining technology, as the founding base of CRM, can help the airlines to effectively capture valuable information about passengers from extensive information available in their databases, which is essential for making strategic marketing decisions. McIvor (2003), state that through sophisticated Information Systems available now, it has become possible to automatically inform staff about customer preferences such as aisle seats or in-flight entertainment. Previously, such information may have been collected but not used to enhance the needs of their most profitable customers. CRM and Data Mining allow companies to target groups effectively, and allocate marketing resources to best effect. As is shown in 80/20 rule, 80% of sales of a company come from 20% of its clients, it is essential to conduct customer segmentation and find those 20% of high-value customers. Zhang and Chen (2009), state that in order to better ensure continued profitability it is necessary to keep customer satisfied. Through a lot of accumulation of data on passenger satisfaction surveys, using data mining technology such as principal component analysis, factor analysis to identify the main influencing factors of passenger satisfaction, as well as the relative importance of various factors can help airlines make improvements, enhance the overall customer service levels and the competitiveness of companies. McIvor et al. (2003), further state that Airline loyalty programmes have been the major means of keeping customers to a particular airline. Airline loyalty programmes provide significant value to customers. Airlines are now associating their Loyalty Programmes with the complementary products and services such as car rentals and hotel accommodations. In fact, the airlines are attempting to create a one-stop shopping experience for the customer with all the required travel products and services available on-line. With the provision of these complementary services, airlines have enhanced value of the core service. It is, therefore, very important to take full advantage of the data mining and other modern information technology to identify the valuable information about the customers buying pattern and choices and address them in timely fashion to provide more personalized service which will ultimately improve passenger satisfaction and loyalty. Operations and Business Intelligence Negash and Gray (2008), discuss the case of Continental Airlines. They state it as the seventh largest airline in the world with 2300 daily flights to over 200 destinations. An airline, as big as this, and requiring decisions about each take-off and landing, each passengers fare, ground operations, detecting fraud, security and customer relations, need for a ICT based intelligent business model was indispensable. In 1998 they implemented a real-time data warehouse and began their climb to being a top airline. For example, they integrated customer information, finance, flight information, seat inventory, and security to improve revenue. The warehouse data also allowed them to spot travel agent fraud. They moved forward from there to real-time applications. For example, they began using optimization techniques to design fares based on current demand; they gave their gate agents and flight attendants details on customer experiences on previous flight segments and flights; if a connecting flight was late, they used dashboard displays so their high-value customers would be helped in making connections for themselves and for their baggage. To make all this work, Continental built an 8 terabyte real-time data warehouse (called an operational data store or ODS) that coordinated 25 internal and two external operational systems. These systems include both Web and desktop BI. In-flight Entertainment The advancement in technology has enabled Airlines to enhance the passengers travelling experience. Back in early 1920s, Aeromarine Airways pioneered in the digital entertainment of passengers by showing a movie during the flight. Since then, digital technologies have evolved from single shared screen to individual screens offering variety of infotainment stuff such as movies, games, news, flight information, weather information etc. Furthermore, as reported by Nelson (2010), in-flight WiFi internet access was made available to passenger in 2008 by American Airlines after the test in 2005. The capability of providing internet facility during the flight has phenomenal impacts and lets the passenger stay in touch with the world even on the go. Security Future As discussed in essay, opportunity for in-flight WiFi access still exists. Few major airlines, like American Airlines, have already provided this facility on certain airlines. Provision of the internet and staying in touch during the longer hours travel will have considerable implications and will be great source of providing competitive edge. Furthermore, reported by HotHardware, BlueBox Avionics is aiming to integrate iPad into their next in-flight entertainment solution. Whether or not they integrate the iPad to the back of the passengers seat, distributing the iPad among the passengers during a long flight will certainly enhance the passengers experience. iPad certainly provides a much richer entertainment as compared to currently installed display screens. Conclusion The evidence presented in this article has illustrated how the Internet represents a powerful technology for commerce and communication between customers and airline companies. The Internet clearly enables the customer to move from being a passive participant to that of being proactive and more sophisticated in their relationship with airlines.
Monday, August 19, 2019
Effectiveness of Scenario Based Simulation Training Essay -- Nursing
Introduction/Problem Statement Across the nation many nursing programs are facing clinical site shortages for their students. The hardest hit population is the license vocational nursing (LVN) students. Many hospitals are trending toward achieving ââ¬Å"Magnet Statusâ⬠for their institutions. Therefore, LVN students are no longer allowed to complete their clinical training in several hospitals. This action forces many nursing programs to seek alternative methods of clinical instruction. In years past simulation training was used as an aid to facilitate learning. Today, for many nursing programs scenario based simulation is the only option for learning patient care. Which brings about the question as to just how effective is simulation training? According to Kneebone, Nestel, Vincent, & Darzer (2007), ââ¬Å"To be effective, however, such simulation must be realistic, patient-focused, structured, and grounded in an authentic clinical context. The author finds the challenge comes not only from technical difficulty but, also from the need for interpersonal skills and professionalism within clinical encountersâ⬠(p. 808). Most mannequins do not have vocal ability or the ability to move, and therefore cannot provide the proper a spontaneous environment for learning. Therefore, acquiring critical thinking skills can be somewhat challenging, in this type of simulated setting. Criteria for evaluating simulations According to (Kneebone at el. 2007 p.812) the following items are criteria for simulation Simulations should allow for sustained, deliberate practice within a safe environment, ensuring that recently acquired skills are consolidated within a defined curriculum which assures regular reinforcement. .. ...006). Effect of practice on standardised learning outcomes. Medical Education, 40(8), Retrieved from http://0-web.ebscohost.com.lib.utep.edu/ehost/pdfviewer/pdfviewer?vid=12&hid=106&sid=265b8200-d816-4fa5-aa4f-f99400f42b76%40sessionmgr104 doi: 10.1111/j.1365- 2929.2006.02528.x National League of Nursing, NLN. (2006, May-June). Designing and implementing models. Retrieved from http://www.nln.org/research/LaerdalReport.pdf Smith, S., & Roehrs, C. (2009). High fidelity simulation: factors correlated with nursing student satisfaction and self confidence. Nursing Education Perspectives, 30(2), p.p. 74-78 Simpson, R. (2002, September 1). The Virtual reality revolution: Nursing Management , 33(9), Retrieved from http://0-web.ebscohost.com.lib.utep.edu/ehost/pdfviewer/pdfviewer?vid=34&hid=112&sid=8d3b1644-95ad-471b-a8c3-5c0c325fa183%40sessionmgr104
Essay on Yeatsian and Western Influences on Chinua Achebes Things Fall
Yeatsian and Western Influences on Things Fall Apart à à à The Igbo culture is flexible and continuous; its laws are made by men and are not solid and permanent. Change is implicit in oral culture. Igbos have been able to retain their core beliefs and behavior systems for 5000 years because of the flexibility and adaptability of their culture. Yeats says things collapse from within before they are overwhelmed by things from without- Umuofia's collapse is its loss of faith, and that is also its strength, it's refusal to fight. But this self-destruction, this bending of societal codes is what keeps the culture from being annihilated. One fundamental question that occurs while trying to figure out how Yeats fits into an understanding of this book is whether or not things really do fall apart. From Okonkwo's point of view they certainly do, but Okonkwo's is not the only point of view in the book. Do things fall apart for the rest of the Umuofia tribes, and for the Ibo people, or does their center still hold, and it is just a center that they never shared with Okonkwo? It is important to look at the construction of the novel and the way it ties in with Yeatsian theory on the rise and fall of civilizations, and on personal tragedy. à The Yeatsian vision of Western history is of a world of "alternating civilizations, each giving way to one another through its inability to contain all human impulses within the enclosed scheme of value and being replaced by all that is overlooked and undervalued"(Wright 80). A fundamental principle of Yeats' vision is that things must "collapse from within before they are overwhelmed from without" (Wright 79). The falcon must lose the connection with the falconer before the center begins to l... ...escapeÃâ°He wiped his machete on the ground and went away" (205). An enduring aspect of the center of the Igbo people is the ability of that center to change and adapt. In an unchanging time, OkonkwoÃâ¢s inflexible will guaranteed his success as a clansman of the Igbo, a culture remarkable for its flexibility, but when the culture had to change to prosper, Okonkwo lost his center, and became a truly tragic figure. à Works Cited Kartennar, Neil ten. "How the Center is Made to Hold in Things Fall Apart." English Studies in Canada. Downsview, Ont. University of Toronto Press. 1975 Simola, Raisa. "World Views in Chinua AchebeÃâ¢s Works." Frankfurt am Main: New York. 1995. Wright, Derek. "Things Standing Together: A Retrospective on Things Fall Apart." Heinemann. Oxford; 1990. Chinua Achebe: A Celebration. Ed. Holst, Peterson. Rutherford. à Ã
Sunday, August 18, 2019
Offshore Outsourcing Essay -- Outsourcing Economics Economy Essays
Offshore Outsourcing Currently, it has been reported that many of our jobs, as much as one out of every three private-sector jobs are being sent overseas. What is offshore outsourcing? Outsourcing occurs when a firm subcontracts a business function to an outside supplier. Outsourcing is mainly the result of companies who will always pursue the lowest-cost structure, which means less skilled work will move out of the U.S. to emerging economies. Many believes that this is a good thing, because living standards around the world will rise, and workers in developing nations will get new and higher-paying jobs, and consumers in the U.S. will be able to buy products that are cheaper than if they were made at home. This paints a scenario where everyone seems to be at the winning end right? This expansion of labor has provoked many controversial debates questioning whether sending so many American jobs overseas is healthy for our economy. One side of the argument is that with the sudden increase in outsourcing high-technology and professional jobs, that we may be in danger of being on the fast-track to becoming a third world country and that our position in the world as the lead economic power might be in jeopardy. On the other side, people are arguing that even though offshore outsourcing forces our economy to suffer job losses that it is only temporary and that the long term benefits will outweigh the short term suffering. The question is, just how serious for America, itsââ¬â¢ workforce, and its economy is the shift? Many supporters for outsourcing defends the process, optimistic, referring to two decades ago, during the loss of auto jobs and other high-paying manufacturing jobs wh... ...hat this will help create win-win solutions and ensure that everyone benefits from a more competitive and healthier global economy. Bibliography Minoli, Daniel. Analyzing Outsourcing. 1995 Johnson, Mike. Outsourcing in brief. 1997 Raynor, William. Outsourcing Jobs Off-Shore: Short and Long-Term Consequences. 2003. The State University of New York. http://www.newwork.com/Pages/Opinion/Raynor/Outsourcing%20Consequences.html Kling, Arnold. Please, Outsource to My Daughter.2003. TCS: Tech Central Station. http://www.techcentralstation.com/071403D.html Steidtmann, Carl. The Macro-Economic Case For Outsourcing.2003. A Deloitte Research Economic Brief. http://www.dc.com/research McKinsey Global Institute. Offshoring: Is It a Win-Win Game? 2004. http://www.mckinsey.com/knowledge/mgi/reports/offshore.asp http://www.rppi.org/offshoringwinwin.shtml
Saturday, August 17, 2019
Comparison Of Good Clinical Practices Health And Social Care Essay
Good Clinical Practices are some of the guidelines to be purely followed while carry oning clinical tests on human topics. There are different GCPs which are fundamentally similar guaranting the well being of topics, and besides good and ethical behavior of clinical surveies of new drugs every bit good as approved drugs. Assorted calamities such as sulfanilamide calamity, Nazi homo trails, thalidomide calamity, and pox survey at Tuskegee lead to the creative activity of different regulations for conductivity of clinical tests and besides good clinical patterns. GCP is an international scientific for proper design, ethical behavior, and coverage of clinical tests affecting human topics. Basically it is a set for regulations that protect the human topics from any injury due to take parting in the survey and to mistakes and errors to maximum and minimum agony for the topics. FDA ( Food and Drug Administration ) expanded and included GMP in 1963, IRBs in 1973 and GCP in 1977.Duties:WHO GCP guidelines are divided into different chapters which describe duties of different personalities concerned with the behavior of clinical tests. The IRB/IEC is responsible for the safety, good being and safeguarding the rights of human topics. IRB is responsible for reexamining the proposal, test site, capable enlisting & A ; informed consent signature, amendments, research worker ââ¬Ës booklet, research worker ââ¬Ës CV etc. The research worker should be a qualified individual, exhaustively familiar with the investigational merchandise by the patron, audit and inspect the merchandise and conformity with GCP. Investigator has the duty of making indispensable paperss for two old ages after blessing of drug, documenting fiscal understandings with patron and research worker, happening of Serious Adverse Events, expiration of trails prematurely.MEDICAL CARE FOR SUBJECTS:A qualified medical practician should take test related medical determinations. If necessary the household physician of the topic should be informed about the topic ââ¬Ës engagement in test.INFORMED CONSENT OF SUBJECTS:The topics should be informed about the process both orally and visually and must acquire a signed informed consent signifier and this should be approved by IRB/IEC. An impartial informant is required in instance the topic could non compose and read.RESPONSIBILITIES OF SPONSOR:Quality confidence and quality control with SOPs, choice of research workers, delegating a proctor, information sing IP merchandise and its use, indemnifying topics, besides assists in the readying of presentment to reexamine board and to investigator.WHO GCP GUIDELINESIt is a set of guidelines globally applicable for the behavior of biomedical research of pharmaceutical merchandises on human topics. Biding these guidelines will assist in the common exchange of clinical research informations between interested states. States which do non hold their ain guidelines can follow WHO guidelines as a portion or whole, as a footing on which clinical tests will be conducted.PROVISIONS AND PREREQUISITES FOR A CLINICAL TRIAL:The clinical test should be ethically justified. It should be on the footing of ethical rules laid by the Declaration Of Helsinki, and the three chief rules of justness, beneficence and regard. There should be proper and echt Preclinical day of the month should to formalize the test. The research worker should be qualifi ed and adept to take up clinical research. The test should run into all the regulative demands.Protocol:The test should be held harmonizing to the written protocol signed by patron and research worker. The protocol appendices should be monitored and approved by the moralss commission.PROTECTION OF THE TRIAL SUBJECTThe personal unity and public assistance of the test topics as defined in the Declaration of Helsinki should be the chief concern of clinical test. Any alterations from DOH should be documented and reported. The moralss commission has been set up for the protection of human topics in test. The research worker and the patron must confer with and subject the proposed protocol. Apart from the blessing the moralss commission will make an on-going monitoring of the clinical test procedure. For the intent of guaranting safety of the test subjects a procedure called Informed Consent procedure is done and this IC papers should be submitted to the EC prior to the beginning of test. Informed consent should be given both orally and written and besides should acquire it signed. Any information that becomes available during the test which may be of relevancy to the test topic must be made known to the research worker. Apart from the test topic, legal defender and the household physician should be informed about the engagement of the topic in the clinical test. The research worker must keep confidentiality of the information sing the topics.RESPONSIBILITIES OF THE INVESTIGATOR:Adequate medical attention for the topics is the duty of the research worker. He must be a qualified and experienced in the medical specialty or dental medicine harmonizing to the protocol and should hold a thorough cognition about the procedure of clinical test. The research worker is responsible for the choice of the test topics. Other duties of the research worker includes rigorous attachment to the accepted protocol, giving equal information sing the test to the topic, giving information about the merchandise to the staff, subjecting inside informations sing the test to the regulative authorization, guaranting the protocol has been reviewed and approved by the moralss commission, describing any serious inauspicious reactions to the patron and regulative authorization, accepting scrutinizing or review by regulative commissions and proctor, subjecting concluding study based on the test which is documented and signed by the research worker. The research worker must inform regulative authorization, patron and whomever applicable in instance of premature expiration of survey.RESPONSIBILITIES OF SPONSOR:The patron is responsible for the choice of research workers, conformity of the process with GCP, supplying investigational merchandise, supplying research workers with research worker ââ¬Ës booklet, supply of investigational merchandise, naming commission or members to oversee the test, supplying compensation to test topics in instance of inadvertent hurt being partic ipated in test, quality confidence, guaranting the readying of appropriate blessing of concluding clinical survey study for regulative governments sing the test. Amendments to the protocol which may impact the safety of the topic should be informed to the EC straight by the patron or through the research worker. If the patron wishes to end the survey the same must be informed to investigator and the authorization. The patron is responsible for the quality confidence of the trail guaranting that all the patterns are recorded and reported harmonizing to GCP and the protocol.RESPONSIBILITIES OF MONITOR:The proctor is a individual appointed by the patron and acts as a communicating between the patron and the research worker. He is responsible for supervising the advancement of the test, commanding the attachment to the protocol, guaranting the informations are right reported and recorded, corroborating the inform consent from the topics, appraisal of test site, educating the staff, assists the research worker in describing the information to the patron, information direction, guaranting right filling of CRFs, assists the research worker in advising the drug regulative of the clinical test and subjecting any necessary certification, record the inside informations of each visit to the test site and the phone calls made.Monitoring OF SAFETY:The patron should supply particular signifiers to describe i nauspicious effects. The national ordinances require patron and/ research worker to describe the inauspicious events to regulative authorization. The research worker has to describe any inauspicious events to patronize, regulative authorization every bit good as EC. During the test the patron is responsible for describing test related AE.Record KEEPING AND HANDLING OF DATA:The overall duty of truth and completeness of the study is on research worker. The record should be signed by patron, research worker every bit good as statistician. The research worker should keep a confidential record of unambiguous codifications to place the topics. Monitor should take steps to avoid losing of informations. The patron must be able to place the informations entered for each topic utilizing the codification ; besides he must do a list of individuals who are authorized to do corrections to the information. The patron has to retain all the paperss, protocols, certifications, review studies etc.Stat isticss AND CALCULATIONSIt should be done by a biostatistical expert. The certain codification used for blinding and randomisation should be with both patron and research worker.Handling OF PHARMACEUTICAL PRODUTSThe patron is responsible for the safety of the merchandise to be tested on human topics and should be of sanctioned quality. Everything sing the storage and despatch of the merchandise must be recorded and the research worker should non provide the investigational merchandise to anyone who is non supposed to have it. The patron is responsible for the proper packaging and labeling of the IP. The research worker has to utilize the merchandise harmonizing to the protocol and has to return the fresh merchandise. It is the duty of the proctor to look into the termination of the IP and should guarantee that it has non exceeded the day of the month of termination.ROLE OF DRUG REGULATORY AUTHORITYThey should guarantee that the proposed protocols are submitted in progress and are ap proved harmonizing to the national ordinances. They should measure the adequateness of oversing the test harmonizing to the studies of the proctor to the patron. They may transport out on site supervising.MULTICENTRIC TRIALSThey require particular administrative system which depends on the terminal point and the cognition of the IP involved. A coordinative commission could be set up with the duty of commanding the public presentation and advancement of test and keeping contacts with the drug regulative authorization.ICH GCP GUIDELINESPrinciplesClinical tests should be conducted in conformity with the ethical rules harmonizing to Declaration of Helsinki, GCP and the applicable regulative demands. Foreseeable hazards and incommodiousnesss should be weighed against the awaited benefits. The rights, safety, and wellbeing of the test topics are the most of import considerations Nonclinical and clinical information on an investigational merchandise should be equal for the test. Should be scientifically sound, and described in a clear, elaborate protocol. A test should be conducted in conformity with the protocol that has reviewed by IRB/IEC The medical attention should be given by a qualified doctor or a tooth doctor. Each person involved in carry oning a test should be qualified by instruction, preparation and experience. Freely given informed consent should be obtained from every topic prior to clinical test engagement. All clinical test information should be recorded and reported. The confidentiality of records that could place topics should be protected. Investigational merchandises should be manufactured, handled, and stored in conformity with GMP and used in conformity with the approved protocol. Quality confidence of systems and processs.IRB/IECThe IRB should dwell of at least five members from assorted Fieldss of life and qualified 1s. Its duties include: To see the makings of the research worker, Continuing reappraisal of each on-going test at intervals, Protection of the rights, safety and/or wellbeing of the topics, Consent of the topic ââ¬Ës lawfully acceptable representative, in instance of non curative tests, Reviewing both the sum and method of payment to topics to guarantee their safety and rights. Merely those IRB/IEC members who are independent of the research worker and the patron of the test have the right to vote or supply sentiment on a trial-related affair. It should work harmonizing to the written SOPs and should follow with GCP. IRB/IEC should do its determinations at proclaimed meetings at which at least a quorum, as stipulated in its written operating processs, is present. IRB/IEC should advise the patron in composing sing its test related sentiments, determinations etc. it should retain all the paperss.Research workerThe research worker should be qualified by instruction and preparation, and should be exhaustively familiar with IP. The research worker could implement alterations in protocol without anterior consent from IRB/IEC if it is believed to do inauspicious reactions and subsequently on informations has to be submitted with justification to IRB/IEC for reappraisal and blessing, to the patron and regulative governments. Research worker is responsible for obtaining IC. Non curative tests should be conducted with the consent of topic ââ¬Ës lawfully acceptable representative. When in exigency that could n't take consent of the topic, consent from LAR is necessary. Essential paperss should be retained for a lower limit of two old ages after the blessing or even longer period if insisted by the regulative demands.PatronThe patron is responsible for procuring understanding from all parties involved to hold a direct entree to all test related sites, paperss and repots for review by domestic and foreign regulative governments. Sponsor may reassign one or all of his test related responsibilities to CRO. He should denominate qualified medical forces. Sponsor may set up an independent information monitoring commission ( IDMC ) to measure the advancement of a clinical test. Any transportation of the ownership of the paperss should be decently documented and the patron should retain all patron specific papers s. The patron is responsible for supplying compensation to the topics, IP, IRB blessing. He appoints proctor, who monitors processs and studies.INVESTIGATOR ââ¬ËS BROCHUREInvestigator ââ¬Ës booklet is a digest of all clinical and non clinical informations on the IP provide by patron relevant to the survey merchandise on human topic. It should be simple, concise, nonsubjective and non promotional that enables the clinician or possible research worker to understand it and do his /her ain indifferent hazard benefit assessment rightness of the test. An extended IB is non required if the merchandise ââ¬Ës pharmacological medicine is widely understood by the medical practicians. It should be renewed yearly and reviewed harmonizing to the patron ââ¬Ës written processs. Sponsor should do certain that an up to day of the month IB is made available to the research worker. IB should incorporate a rubric page and a confidentiality statement. It contains table of contents, debut, belongingss of preparation, consequence on worlds, and counsel for the research worker.Essential DOCUMENTSEssential paperss are those which permit the rating of the behavior of the trail and the quality of the informations produced. They demonstrate the conformity of the research worker, patron and proctor with the criterions of GCP and other regulative demands. Essential paperss are inspected by regulative governments and audited by patron ââ¬Ës independent audit map. They are grouped into three subdivisions harmonizing to the phase of trail where in it is generated. One before the beginning of clinical test, the 2nd one during the behavior of the test and 3rd one after the expiration of test. Trial maestro files should be established at the beginning of the test, both at the research worker ââ¬Ës and patron ââ¬Ës office. A concluding stopping point out of the file can be done merely when both the research worker and patron files are re viewed by the proctor and confirmed that all necessary paperss are in appropriate files.INDIAN GCPThe clinical test should be supported by pre clinical informations on the IP back uping the proposed protocol. The protocol should incorporate an appropriate survey design, inclusion exclusion exclusion standards, quality control and quality confidence, ethical and safety considerations which includes the rule of essentialness, rule of voluntariness, IC and community understanding, rules of non development, rules of privateness and confidentiality, rules of safeguard and hazard minimisation, rules of professional competency, rules of answerability and transparence, rules of maximization of the public involvement and distributive justness, rules of institutional agreements, rules of public sphere, rules of entirety of duty, rules of conformity.ETHICS COMMITTIEE:They review and O.K. protocol. Harmonizing to Indian GCP the commission should consists of lower limit of 5 members and a upper limit of 12 to 15. There should be equal representation of age, gender, community etc. the ethical reappraisal should be done through formal meetings and consensus. The research worker should subject an application in the prescribed format along with the protocol at least 3 hebdomads in progress. The IEC should be able to supply complete reappraisal of the proposals and should inform their base by composing to the patron.INFORMED CONSENT AND SPECIAL GROUPS:In instance of non-therapeutic surveies the consent should be given by the topic. Pregnant or nursing adult females should non be a capable unless the research carries no more than minimum hazard. Research related to expiration of gestation could be conducted in adult females who wish to make MTP. Pregnant adult females can besides be included if he study is sing techniques to observe foetal abnormalcies. Children should non be included in research that could be carried out every bit good with grownups. IC should be obtained from parents every bit good from the kid and the kid should be made cognizant about the test procedure and his/ her refusal to take part in the clinical test is considered. Adequate justification is required while enrolling vulnerable topics.DutyThe patron is responsible for research worker choice. The patron should come in into a legal and formal contract with institute/ research worker, sing conformity with GCP, entering and coverage, scrutinizing review and monitoring. Sponsor has to corroborate the reappraisal by moralss commission, supply information on IP, providing IP, ongoing safety rating of the merchandise, safeguarding survey topics, turn outing ADR/ AE describing signifiers to the research worker, guaranting appropriate readying of survey studies, naming proctors to supervise the survey, executing audit as portion of QA system, particular agreements in instance of multicentric tests, make agreements to ease communicating between research workers of different test centres. If the patron is a foreign company or individual, it shall name a local representative or CRO to carry through the duties by national ordinances. The guideline mandates that the patron and the research worker should subscribe a transcript of the Standard Operating Procedures ( SOPs ) . Besides, the research worker and his staff have to be cognizant and comply with SOPs. Indian GCP demands that the research worker should subscribe and send on the informations like Case Report Forms ( CRF ) , consequences and readings, analyses and studies of the survey from his/her Centre to the patron and the moralss commission. Monitor should be to the full cognizant of the IP. He oversees the advancement of the survey, observe and describe the capable enlisting rate to the patron, aids investigator in describing he data to patronize, guarantee all CRFs are filled right, subjecting written study to patronize after sing each site, The research worker should hold makings prescribed by MCI. He is responsible for all survey related medical determinations, guaranting the blessing of protocol by moralss commission, indifferent choice of survey topics, answerability of IP at survey site, subjecting written drumhead of the survey study to patronize.RANDOMISATION AND BLINDINGDone to avoid prejudice and there are certain codification to place the topics which are unbroken secret during the survey and broken merely harmonizing to the protocol. The types of statistical analyses used must be clearly identified and should organize the footing of the survey.Particular Concerns:Clinical tests for vaccinumsSponsor and research worker should be cognizant of the procedure for carry oning clinical tests affecting vaccinums. They should be familiar with the guidelines provided by DCGI, DBT and GEAC. Subjects should be informed if they are injected with unrecorded or attenuated micro-organisms. There should be equal research lab i nstallations and besides installations for the laboratory rating of seroconversion. Blessing from IEC should be ensured by the patron. Post selling surveies are required following seroconversion surveies. Relevant information sing the quality control is compulsory.Clinical tests for preventives:Subjects should be informed about the options. Children borne due to failure of preventives should be medically followed. Proper followup for the remotion of implant is necessary if implant is used as a preventive for test.Clinical tests with surgical procedures/medical devices:Animal safety informations is required. Phase 1 tests are non required as tests with medical devices can non be done on healthy voluntaries. Safety processs should be followed for the debut of medical devices. Informed consent should be followed as in with drug tests.Diagnostic agents- radioactive stuffs and ten beams:Informed consent should be obtained and the topics should non be exposed to radiation more than that o f normal. Research should be done on patients undergoing processs for diagnostic or curative intents. Safety steps should be taken to protect them. Pregnancies should non be included to avoid hazards to embryo. Non radioactive diagnostic agents are considered as drugs and are to follow the same guidelines of drugs.Herbal redresss and medical workssPhase 1 surveies are non necessary and the plat and herbal redresss are presently in usage or mentioned in literature of traditional medical specialties and are prepared harmonizing to GMP. Toxicity surveies are non required for stage 2 tests if it is non found toxic when used for more than 3 months. Clinical tests with herbal merchandises should be carried out merely after standardisation and development of marker. Trails have to acquire blessing from regulative governments. Tests should be held in the presence of competent ayurvedic, siddha, unani doctor as co-investigator on in such a test.
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